Generally, there are 2 types OS bootable from USB.
Although other OS,like Mac OS X can boot from USB directly, but a Mac compatible system required.
REM sudo / admin rights REM physical drive 0-9 depends on your device NO. found, for this case, it is "PhysicalDrive1" VBoxManage internalcommands createrawvmdk -filename \VM\myUSB.vmdk -rawdisk \\.\PhysicalDrive1